EXPLORING THE GENOME
We use modern genomics techniques and high-throughput experiments to explore biological systems. We can leverage computational tools to help answer biological problems that were previously intractable. We aim to combine computational approaches with high-throughput biological assays to better understand the whole human transcriptional regulatory system.
From Principal Investigator, Alan P. Boyle, Ph.D.
Understanding gene regulation at the transcriptional level is critical to understanding complex biological systems and human disease. In virtually all organisms gene regulation is mediated by a “regulatory code” in which distinct combinations of specific transcription factors collaborate to regulate the expression of individual genes.
This code is complex and not readily obvious from sequences alone.
It likely involves many cis-regulatory modules that exist both upstream and within genes.
In addition, mounting evidence suggests that major differences between individuals and species lie at the level of gene regulation and that changes in cis-regulatory sequences are responsible for these effects.
Our research aims to explore this regulatory code by examining the cis-regulatory elements in the human genome.
February 01, 2017 - Lab receives grant to support RegulomeDB!
January 19, 2017 - The Boyle Lab joins the Cellular & Molecular Biology program at UM.
January 17, 2017 - Our review on noncoding SNP annotation is published in Trends in Genetics!