Exploring the Genome
We use modern genomics techniques and high-throughput experiments to explore biological systems. We leverage computational tools to answer biological questions that were previously intractable, combining computational approaches with high-throughput biological assays to better understand the human transcriptional regulatory system.
From Principal Investigator, Alan P. Boyle, Ph.D.
Understanding gene regulation at the transcriptional level is critical to understanding complex biological systems and human disease. In virtually all organisms, gene regulation is mediated by a “regulatory code” in which distinct combinations of specific transcription factors collaborate to regulate the expression of individual genes. This code is complex and not readily apparent from sequence alone. It likely involves many cis-regulatory modules that exist both upstream of and within genes. In addition, mounting evidence suggests that major differences between individuals and species lie at the level of gene regulation and that changes in cis-regulatory sequences are responsible for these effects.
Our research aims to explore this regulatory code by examining the cis-regulatory elements in the human genome.
Find Us
Ann Arbor, Michigan
Our computational offices are in Medical Science Unit I, and our wet laboratory is in Medical Science Building II on the University of Michigan Medical Campus.
Maps and contact information