Papers July 2, 2025

The SMaHT Network marker paper is published in Nature!

The SMaHT Network marker paper is published in Nature! The SMaHT Network marker paper describes an ambitious effort to build a reference catalog of somatic mutations and clonal patterns across 19 tissue sites from 150 non-diseased donors. The network will combine large-scale tissue sampling with new sequencing technologies, computational methods, and rigorous benchmarking to reveal how somatic variation accumulates across the body and contributes to aging, health, and disease. The Boyle Lab is proud to contribute through our SMaHT technology-development project jointly with the Mills lab, including new approaches for detecting somatic mobile-element insertions and other difficult-to-measure variation. Congratulations to the entire SMaHT Network and the Boyle Lab members contributing to this collaborative work!

Research output

The Somatic Mosaicism across Human Tissues Network

Coorens THH , Oh JW , Choi YA , Lim NS , Zhao B , Voshall A , Abyzov A , Antonacci-Fulton L , Aparicio S , Ardlie KG , Bell TJ , Bennett JT , Bernstein BE , Blanchard TG , Boyle AP , Buenrostro JD , Burns KH , Chen F , Chen R , Choudhury S , Doddapaneni HV , Eichler EE , Evrony GD , Faith MA , Fazzio TG , Fulton RS , Garber M , Gehlenborg N , Germer S , Getz G , Gibbs RA , Hernandez RG , Jin F , Korbel JO , Landau DA , Lawson HA , Lennon NJ , Li H , Li Y , Loh PR , Marth G , McConnell MJ , Mills RE , Montgomery SB , Natarajan P , Park PJ , Satija R , Sedlazeck FJ , Shao DD , Shen H , Stergachis AB , Underhill HR , Urban AE , VonDran MW , Walsh CA , Wang T , Wu TP , Zong C , Lee EA , Vaccarino FM , Somatic Mosaicism across Human Tissues Network

Nature 2025 643(8070):47-59

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