Our paper on mapping somatic retrotransposition is published in Cell Genomics! This SMaHT collaboration establishes a multi-platform framework for detecting rare somatic mobile element insertions by integrating short-read, long-read, and mobile-element-targeted sequencing with haplotype phasing, donor-specific genome assemblies, and LINE-1 source tracing. Applying the framework to brain, liver, lung, and colon tissues revealed 18 somatic L1 insertions and substantial structural and source diversity. The Boyle Lab contributed TEnCATS, our Cas9-targeted nanopore sequencing approach, to the cross-platform benchmark. Congratulations to Jessica, Steve, Torrin, Camille, and the entire SMaHT MEI Working Group on this collaborative study!
Our paper on mapping somatic retrotransposition is published in Cell Genomics!
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