Our paper studying the conservation of how transcription factors work in a coordinated fashion to regulate gene expression is published in Nucleic Acids Research. This study learns a regulatory “grammar” from transcription factor co-binding patterns in human and mouse cells. These combinations of factors predict regulatory function more reliably than sequence position alone and reveal how conserved logic and species-specific rewiring jointly shape gene expression and disease risk. Congratulations to Adam on leading this work!
Our manuscript on conserved co-binding patterns of transcription factors is published in NAR!
People
Boyle Lab members
More from the lab
