Background

Alan Boyle is Professor of Computational Medicine and Bioinformatics and Professor of Human Genetics at the University of Michigan Medical School. He earned his PhD in Computational Biology and Bioinformatics at Duke University, where he developed experimental and computational methods for mapping open chromatin, including DNase-seq. He completed his postdoctoral training in Genetics at Stanford University, where he developed methods for interpreting non-coding genetic variation and contributed to the ENCODE and modENCODE projects. His laboratory combines computational genomics, high-throughput functional assays, and long-read sequencing to understand how variation in regulatory and repetitive regions of the genome alters gene regulation and contributes to human disease. Current research includes interpreting regulatory variants through the IGVF Consortium, developing long-read approaches to study somatic mosaicism through the SMaHT Network, and investigating the effects of mobile elements, tandem repeats, and other structural variants on genome function.